FOXO4-DRI (FOXO4-D-Retro-Inverso) is a synthetic peptide engineered using D-amino acids in a retro-inverso configuration to increase stability against enzymatic degradation. It has been studied in preclinical research for its interaction with the FOXO4–p53 pathway and its role in cellular senescence signaling mechanisms. To date, published data are limited to cell and animal studies.